Scientists have developed a new mathematical model of Alzheimer's disease


Scientists have used a mathematical model to reveal how toxic proteins gather in the brain at the early stage of Alzheimer's disease. Researchers said that this discovery may have an important impact on future treatment.

 

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Researchers from the School of Physics, Engineering and Technology of the University of York said that this discovery may have important significance for future treatment. The research was recently published in Frontiers in Molecular Neuroscience.

 

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Research shows that a major protein related to Alzheimer's disease (amyloid protein) will condense into a droplet like object before forming an aggregation that affects normal brain activity.

Alzheimer's disease is the most common dementia. More than 50 million people worldwide suffer from this disease, which is expected to double by 2050.

At the nanoscale, toxic amyloid proteins in the brain gathered together about 10-15 years before the initial symptoms appeared, but the exact way of their aggregation is still unclear. By accurately understanding the formation process of protein clusters, scientists may more easily develop targeted drug therapies to block them.

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